Audio is completely desynched from animations.
Nvidia GTX 970
Intel i5 3570
ASUS Xonar DSX
All drivers up to date.
Funny that it's the same sort of problem that the old SCUMM engine games had back in the day, especially Full Throttle.
I have the same issue with severe stuttering during cutscenes. Have tried lowering sample rate as low as 16-bit 44100. Lowering "Graphics Quality" does nothing. This is annoying considering the game barely crests such staggering usage as 22% on my cpuand 15% gpu. Seems to be the issue of trying to push everything on a single core of the cpu. Possible software rendering issue for the sound? Was an issue for the Darksiders Warmastered edition as I recall.
Try setting your your speaker's sample rate down to 24 bit, 48000 hz.